Chief cells secrete inactive pepsinogen, which is activated to pepsin when mixed with hydrochloric acid in the stomach.
Mucus protects the stomach lining from gastric juice.
Slide 43
The stomach and its secretions
Interior surface of stomach
Esophagus
Chief cells
Small intestine
Epithelium
Stomach
Sphincter
Parietal cell
Pepsinogen
and HCl are secreted.
HCl converts pepsinogen to
pepsin.
Pepsin activates more pepsinogen.
Chief cell
Folds of epithelial tissue
Pepsin
Sphincter
Pepsinogen
HCl
H+
Cl–
Parietal cells
Mucus cells
Gastric gland
1
2
2
3.
3
3
1
5 µm
Slide 44
Gastric ulcers, lesions in the lining, are caused mainly by the bacterium Helicobacter pylori.
Coordinated contraction and relaxation of stomach muscle churn the stomach’s contents.
Sphincters prevent chyme from entering the esophagus and regulate its entry into the small intestine.
Slide 45
The small intestine is the longest section of the alimentary canal.
It is the major organ of digestion and absorption.
Slide 46
Enzymatic hydrolysis in the human digestive system
Oral cavity, pharynx, esophagus
Stomach
Lumen of small
intestine
Epithelium of small intestine (brush border)
Carbohydrate digestion
Polysaccharides
Smaller polysaccharides, maltose
Polysaccharides
Maltose and other disaccharides
Disaccharides
Protein digestion
Nucleic acid digestion
Fat digestion
Proteins
Small polypeptides
Pepsin
Pancreatic amylases
Salivary amylase
Disaccharidases
Monosaccharides
Small peptides
Amino acids
Amino acids
Polypeptides
Smaller polypeptides
Pancreatic trypsin and chymotrypsin
Pancreatic carboxypeptidase
Dipeptidases, carboxypeptidase, and aminopeptidase
DNA, RNA
Pancreatic nucleases
Fat globules
Nucleotides
Fat droplets
Nucleosides
Nitrogenous bases, sugars, phosphates
Nucleotidases
Nucleosidases and phosphatases
Glycerol, fatty acids, monoglycerides
Bile salts
Pancreatic lipase
(starch, glycogen)
(sucrose, lactose)
Slide 47
The first portion of the small intestine is the duodenum, where acid chyme from the stomach mixes with digestive juices from the pancreas, liver, gallbladder, and the small intestine itself.
Slide 48