Cellular Respiration Harvesting Chemical Energy

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1, 3-Bisphosphoglycerate

3-Phosphoglycerate

Phosphoglycero-

kinase

2

7

Slide 36

Fig. 9-9-7

3-Phosphoglycerate

Triose phosphate

dehydrogenase

2 NAD+

2

NADH

+ 2 H+

2

P

i

2

2 ADP

Phosphoglycerokinase

1, 3-Bisphosphoglycerate

2 ATP

3-Phosphoglycerate

2

Phosphoglyceromutase

2-Phosphoglycerate

2

2-Phosphoglycerate

2

2

Phosphoglycero-

mutase

6

7

8

8

Slide 37

Fig. 9-9-8

2 NAD+

NADH

2

2

2

2

2

+ 2 H+

Triose phosphate

dehydrogenase

2

P

i

1, 3-Bisphosphoglycerate

Phosphoglycerokinase

2 ADP

2 ATP

3-Phosphoglycerate

Phosphoglyceromutase

Enolase

2-Phosphoglycerate

2 H2O

Phosphoenolpyruvate

9

8

7

6

2

2-Phosphoglycerate

Enolase

2

2 H2O

Phosphoenolpyruvate

9

Slide 38

Fig. 9-9-9

Triose phosphate

dehydrogenase

2 NAD+

NADH

2

2

2

2

2

2

2 ADP

2 ATP

Pyruvate

Pyruvate kinase

Phosphoenolpyruvate

Enolase

2 H2O

2-Phosphoglycerate

Phosphoglyceromutase

3-Phosphoglycerate

Phosphoglycerokinase

2 ATP

2 ADP

1, 3-Bisphosphoglycerate

+ 2 H+

6

7

8

9

10

2

2 ADP

2 ATP

Phosphoenolpyruvate

Pyruvate kinase

2

Pyruvate

10

2

P

i

Slide 39

Concept 9.3: The citric acid cycle completes the energy-yielding oxidation of organic molecules

In the presence of O2, pyruvate enters the mitochondrion

Before the citric acid cycle can begin, pyruvate must be converted to acetyl CoA, which links the cycle to glycolysis

Slide 40

Fig. 9-10

CYTOSOL

MITOCHONDRION

NAD+

NADH

+ H+

2

1

3

Pyruvate

Transport protein

CO2

Coenzyme A

Acetyl CoA

Slide 41

The citric acid cycle, also called the Krebs cycle, takes place within the mitochondrial matrix

The cycle oxidizes organic fuel derived from pyruvate, generating 1 ATP, 3 NADH, and 1 FADH2 per turn

Slide 42

Fig. 9-11

Pyruvate

NAD+

NADH

+ H+

Acetyl CoA

CO2

CoA

CoA

CoA

Citric

acid

cycle

FADH2

FAD

CO2

2

3

3 NAD+

+ 3 H+

ADP +

P