NMR for diagnosis and drug design

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Assess blood flow in major vessels.

INVIVO SPECTROSCOPY

Chemical shift phenomenon

Diagnosis of rare disease to inborn errors- Mc Ardle’s syndrome

INVIVO Analysis of Bone flouride content.

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Putting Nmr Imaging Into Perspective

Eliminates risk of x-radiation

Excellent spatial & contrast resolution

Detecting diseases at earlier stages

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Nmr In Pharmaceutical Research

Leading technology for 3-D structure determination of bio-macromolecules

Studying protein structure

SAR by NMR – Novel lead compounds

Chemical shift mapping – Structural information on the binding modes and site positions

Molecular dynamics, conformational analysis

SHAPES

NMR – SOLVE

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Structural genomics

Identifying gene products in disease

Targets of drug design.

Development of Novel drug delivery systems

Enhancing HTS assays

Thousands of compounds

Cryogenic NMR technology / cryoprobes

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NMR Nobel Prize Laureates

The Nobel Prize in Physics 1943, Ohostern, USA – Discovery of magnetic moment of proton

The Nobel Prizein Physics 1952- IsidorJ. Rafi,USA – Discovery of new methods for nuclear magnetic precision

The Nobel Prize in Chemistry 1991 – Felix Bloch, USA and Edward M. Purcell, USA – Methodology of high resolution NMR.

The Nobel Prize in Chemistry 2002 – Kurt Wuthrich, Switzerland – Determining 3-D Structure by NMR.

The Nobel Prize in Medicine 2003 – Paul C. Lauterbur, USA and Peter Mans field, U.K. – Discoveries concerning MRI.

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THANKING YOU